Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam
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چکیده
منابع مشابه
Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam
Although NSAIDs are very effective drugs, their use is associated with a broad spectrum of adverse reactions in the liver, kidney, cardiovascular (CV) system, skin and gut. Gastrointestinal (GI) side effects are the most common and constitute a wide clinical spectrum ranging from dyspepsia, heartburn and abdominal discomfort to more serious events such as peptic ulcer with life-threatening comp...
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The aim of this work was to evaluate the role of cyclodextrins in topical drug formulations. Solid piroxicam (PX) complexes with beta-cyclodextrin (beta-CD) and randomly methylated beta-cyclodextrin (RAMEB) were prepared by freeze-drying and characterized using differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD), Fourier transform infrared spectroscopy (FTIR) and near in...
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Four new crystalline forms of piroxicam have been obtained and studied by single-crystal X-ray structure analysis. These comprise an addition salt with hydrochloric acid, acetic and isobutyric acids solvates, as well as piroxicam and furosemide cocrystal acetone solvate. All these new structures contribute to the variety of already known piroxicam crystalline forms. The analysis of conformation...
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Forming complexes with cyclodextrins can enhance the dissolution rate, the stability, the solubility and the bioavailability of a drug. In this work, piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical carbon dioxide. The influence of temperature, residence time, water content and a ternary agent, L-lysine, were studied. The complex was characterized by Dif...
متن کامل[Fixed drug eruption due to piroxicam].
Piroxicam is a nonsteroidal antiinflammatory drug (NSAID) of the oxicam group and has anti-inflammatory, analgesic, antipyretic, and antiplatelet properties. It is a potent prostaglandin inhibitor with a long half-life in plasma (36-58 hours), meaning that it can be administered in a single daily dose. Multiple adverse systemic effects have been reported for piroxicam, of which the most common ...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2013
ISSN: 0929-8673
DOI: 10.2174/09298673113209990115